Short Course Abstracts 1999
Statistical Genetics: Human Disease Gene Studies
By Bruce Weir, North Carolina State University
June 18, 1999
Fort Washington Holiday Inn
Hotel tel. (215) 643-3000
There is growing use in the pharmaceutical industry of genetic data, both as a predictor of drug response and as an indicator of the location of disease susceptibility loci. Interpretation of these data should be based upon an appropriate evolutionary model in order to accommodate the variation in sample statistics from evolutionary sampling as well as statistical sampling. This joint sampling framework will be described, and then a description given of measures of association between disease status and genetic marker type. The possibilities of extending association mapping of susceptibility loci to quantitative traits will also be covered.